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Pernicious Poison

Source Ultimate Magic pg. 1 (Amazon)
School necromancy [poison]; Level antipaladin 2, arcanist 2, druid 2, hunter 2, occultist 2, sorcerer/wizard 2, witch 2

Casting

Casting Time 1 standard action
Components V, S, DF

Effect

Range touch
Target creature touched
Duration 10 minute/level
Saving Throw none; Spell Resistance yes

Description

You weaken the target’s defenses against poison. The target gains a –4 penalty on saves against poison, and poisons affecting the target continue for another 2 frequency increments (for example, black adder venom lasts 8 rounds instead of 6, and arsenic lasts for 6 minutes instead of 4). Attempts to cure the poisoned target with skill or magic take a –4 penalty.

Mythic Pernicious Poison

Source Mythic Adventures pg. 103
The number of successful saving throws needed to cure a poison increases by one. If the poison deals ability damage on a failed saving throw, that ability damage increases by 1.

Augmented (6th): If you expend two uses of mythic power, the target’s penalty on saves against poison increases to –8, and the penalty for attempting to cure the target with skill or magic increases to –8.

If you expend three uses of mythic power, the poison bypasses the creature’s poison immunity (this doesn’t affect poison immunity from not having a Constitution score).